An Activity-Based Near-Infrared Glucuronide Trapping Probe for Imaging β-Glucuronidase Expression in Deep Tissues

Ta-Chun Cheng, Steve R. Roffler, Shey-Cherng Tzou, +9

Journal of the American Chemical Society

EngineeringNir Glucuronide ProbesGlycobiologyReporter ExpressionMolecular Biology +14

Benzyl Ether-Linked Glucuronide Derivative of 10-Hydroxycamptothecin Designed for Selective Camptothecin-Based Anticancer Therapy

Yu-Ling Leu, Chien‐Shu Chen, Yih-Jang Wu, +1

Journal of Medicinal Chemistry

Compound 7Medicinal ChemistryPharmaceutical ScienceChemoprevention StrategyBiochemistry +12

The β-Carboline Analog Mana-Hox Causes Mitotic Aberration by Interacting with DNA

Lan Chun Tu, Chien‐Shu Chen, I-Ching Hsiao, +4

Chemistry & Biology

ChromatinGenome InstabilityCell DivisionNatural SciencesGenetics +5

Studies on 1,2,4-Benzothiadiazine 1,1-Dioxides VII and Quinazolinones IV: Synthesis of Novel Built-In Hydroxyguanidine Tricycles as Potential Anticancer Agents

Ji‐Wang Chern, Yen‐Chywan Liaw, Chien‐Shu Chen, +4

Heterocycles

Kb.colo 205.Hela.andMedicinal ChemistryHeterocyclicNatural SciencesMedicine +12

Efficient microwave‐assisted synthesis of ellipticine through <i>N</i>‐(1,4‐dimethyl‐9<i>H</i>‐carbazol‐3‐ylmethyl)‐<i>N</i>‐ tosylaminoacetaldehyde diethyl acetal

Hsueh‐Yun Lee, Grace Shiahuy Chen, Chien‐Shu Chen, +1

Journal of Heterocyclic Chemistry

Chemical EngineeringDerivativesEngineeringEllipticine DerivativesHeterocyclic +11

Microwave‐Assisted Cross‐Coupling for the Construction of Diaryl Sulfides

Grace Shiahuy Chen, Chien‐Shu Chen, Ji‐Wang Chern

Journal of the Chinese Chemical Society

Chemical EngineeringCross-coupling ReactionEngineeringMicrowave HeatingApplied Physics +6

Synthesis, Anticonvulsant, Sedative and Anxiolytic Activities of Novel Annulated Pyrrolo[1,4]benzodiazepines

Kumaraswamy Sorra, Chien‐Shu Chen, Chi‐Fen Chang, +4

International Journal of Molecular Sciences

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryPsychoactive DrugPbdt 13 +11

Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors

Chen-Ming Tan, Grace Shiahuy Chen, Chien‐Shu Chen, +2

Bioorganic & Medicinal Chemistry

1,1-Dioxide DerivativesMedicinal ChemistryBioorganic ChemistryHeterocyclicBiochemistry +7

Nucleosides. IX. Synthesis of Purine<i>N</i>³,5′‐Cyclonucleosides and<i>N</i>³,5′‐Cyclo‐2′,3′‐seconucleosides via Mitsunobu Reaction as TIBO‐like Derivatives

Grace Shiahuy Chen, Chien‐Shu Chen, Tun‐Cheng Chien, +4

Nucleosides Nucleotides & Nucleic Acids

Combinatorial ChemistryBioorganic ChemistryMitsunobu ReactionBiochemistryRibose Moiety +9

A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth

Pei‐Teh Chang, Rahul Subhash Talekar, Fan‐Lu Kung, +11

Neuropharmacology

Neurodegenerative DiseasesAlzheimer's DiseaseMolecular NeuroscienceBiochemistryNatural Sciences +9