Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

Tae-Hee Kim, Fugen Li, Isabel Ferreiro-Neira, +6

Nature

Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion

Xushen Xiong, Benjamin T. James, Carles A. Boix, +14

Cell

Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes

Farnaz Shamsi, Mary Piper, Li‐Lun Ho, +5

Nature Metabolism

Signal TransductionMolecular PhysiologyPhysiologyMetabolic RegulationVascular Biology +6

Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells

Jiekun Yang, Maria Vamvini, Pasquale Nigro, +14

Cell Metabolism

Single-cell multi-cohort dissection of the schizophrenia transcriptome

W. Brad Ruzicka, Shahin Mohammadi, John F. Fullard, +213

Science

NeuropsychologyGeneticsSchizophrenia TranscriptomeSocial SciencesSingle-cell Dissection +16

Essential and Redundant Functions of Caudal Family Proteins in Activating Adult Intestinal Genes

Michael P. Verzi, Hyunjin Shin, Li‐Lun Ho, +2

Molecular and Cellular Biology

A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex

Louise A. Huuki-Myers, Abby Spangler, Nicholas J. Eagles, +232

Science

NeurogenomicsHuman Prefrontal CortexBrain MappingBrain OrganizationSpatial Omics +18

Massively parallel characterization of regulatory elements in the developing human cortex

Chengyu Deng, Sean Whalen, Marilyn Steyert, +224

Science

Brain DevelopmentDevelopmental Cognitive NeuroscienceBrain MechanismCerebral OrganoidGene Regulatory Network +21

Penta-O-galloyl-β-d-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1

Li‐Lun Ho, Wei J. Chen, Shoei‐Yn Lin‐Shiau, +1

European Journal of Pharmacology

MedicineMouse MelanomaMelanomaPathologyCancer Cell Biology +6

Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix

Pasquale Nigro, Maria Vamvini, Jiekun Yang, +15

Cell Reports

Muscle FunctionIwat RemodelingMetabolic RemodelingBiomedical EngineeringCellular Physiology +23