Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

Koji Abe, Masashi Aoki, Shoji Tsuji, +73

The Lancet Neurology

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisNeurological DisorderDefined PatientsClinical Neurology +4

Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial

Yukito Shinohara, Yasuo Katayama, Shinichiro Uchiyama, +14

The Lancet Neurology

ThrombosisIschemic StrokeCardiovascular DiseaseMedicineSecondary Stroke +13

Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients

Koji Abe, Yasuto Itoyama, Gen Sobue, +8

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial

Takayuki Yoshino, Nobuyuki Mizunuma, Kentaro Yamazaki, +13

The Lancet Oncology

Placebo-controlled Phase 2Tas-102 MonotherapyGastrointestinal OncologyMedicineClinical Trials +7

Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases

Yasushi Imai, Hiroyuki Morita, Hiroki Kurihara, +8

Atherosclerosis

GeneticsGenetic EpidemiologyHuman PolymorphismPathologyCardiovascular Genetics +8

Relationship between neutrophil elastase and acute lung injury in humans

S Tamakuma, Michio Ogawa, Naoki Aikawa, +7

Pulmonary Pharmacology & Therapeutics

InflammationAsthmaAcute Lung InjuryInflammatory Lung DiseaseLung Inflammation +5

Randomized phase III study comparing the efficacy and safety of irinotecan plus S-1 with S-1 alone as first-line treatment for advanced gastric cancer (study GC0301/TOP-002)

Hiroyuki Narahara, Hiroyasu Iishi, Hiroshi Imamura, +7

Gastric Cancer

Prognostic Factors After Pulmonary Metastasectomy for Colorectal Cancer and Rationale for Determining Surgical Indications

Tomohiko Iida, Hiroaki Nomori, Mitsutoshi Shiba, +12

Annals of Surgery

Methylenetetrahydrofolate Reductase Gene Polymorphism and Ischemic Stroke in Japanese

Hiroyuki Morita, Hiroki Kurihara, Shin-ichi Tsubaki, +7

Arteriosclerosis Thrombosis and Vascular Biology

Impact of postoperative complications on the colorectal cancer survival and recurrence: analyses of pooled individual patients’ data from three large phase III randomized trials

Toru Aoyama, Koji Oba, Michitaka Honda, +9

Cancer Medicine