Synthesis and tumor inhibitory activity of novel coumarin analogs targeting angiogenesis and apoptosis

B.R. Vijay Avin, Prabhu Thirusangu, V. Lakshmi Ranganatha, +3

European Journal of Medicinal Chemistry

Drug TargetingAngiogenesisMedicineTumor Inhibitory ActivityCell Death +9

BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation

Prabhu Thirusangu, V. Vigneshwaran, T. Prashanth, +5

Angiogenesis

Antiangiogenic Benzophenone-thiazole PharmacophoreMedicineAnti-cancer AgentTumor SuppressorPharmacology +2

Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma

T. Prashanth, B.R. Vijay Avin, Prabhu Thirusangu, +4

Biomedicine & Pharmacotherapy

Synthesis, angiopreventive activity, and in vivo tumor inhibition of novel benzophenone–benzimidazole analogs

V. Lakshmi Ranganatha, B.R. Vijay Avin, Prabhu Thirusangu, +3

Life Sciences

Vivo Tumor InhibitionAngiopreventive ActivityChemoprevention StrategyMedicinePharmacological Agent +7

Synthesis and evaluation of novel benzophenone-thiazole derivatives as potent VEGF-A inhibitors

T. Prashanth, Prabhu Thirusangu, B.R. Vijay Avin, +3

European Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryMedicineNovel Benzophenone-thiazole DerivativesPharmacological Agent +6

A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression

Prabhu Thirusangu, V. Vigneshwaran, V. Lakshmi Ranganatha, +5

Biochemical Pharmacology

MedicineNeoplastic ProgressionCancer Cell BiologyTarget Gene ActivationCancer Biology +7

DAO-9 (2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazole) exhibits p53 induced apoptogenesis through caspase-3 mediated endonuclease activity in murine carcinoma

H. D. Gurupadaswamy, Prabhu Thirusangu, B.R. Vijay Avin, +6

Biomedicine & Pharmacotherapy

Oncogenic AgentMedicineApoptosisPathologyCell Death +8

Scutellarein antagonizes the tumorigenesis by modulating cytokine VEGF mediated neoangiogenesis and DFF-40 actuated nucleosomal degradation

Prabhu Thirusangu, V. Vigneshwaran, B.R. Vijay Avin, +2

Biochemical and Biophysical Research Communications

Tumor BiologyDevelopmental BiologyMedicineCytokine VegfCell Proliferation +5

New role of lupeol in reticence of angiogenesis, the cellular parameter of neoplastic progression in tumorigenesis models through altered gene expression

B.R. Vijay Avin, T Prabhu, C Ramesh, +4

Biochemical and Biophysical Research Communications

New RoleAngiogenesisMedicineNatural SciencesCancer Biology +11

Immunomodulatory glc/man-directed<i>Dolichos lablab</i>lectin (DLL) evokes anti-tumour response<i>in vivo</i>by counteracting angiogenic gene expressions

V. Vigneshwaran, Prabhu Thirusangu, B.R. Vijay Avin, +3

Clinical & Experimental Immunology