Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

Rik J. Scheper, H J Broxterman, G L Scheffer, +7

PubMed

Proteinlipid InteractionTumor BiologyDrug ResistanceDrug Transporter MoleculesBiochemical Genetics +15

Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia

CS Spier, TM Grogan, Charles A. Johnson, +7

Blood

Drug Resistance-Associated Marker Lrp for Prediction of Response to Chemotherapy and Prognoses in Advanced Ovarian Carcinoma

M. A. lzquierdo, Ate Gj Van Der Zee, Jan B. Vermorken, +10

JNCI Journal of the National Cancer Institute

The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux.

Charles Erlichman, Scott A. Boerner, Christopher G. Hallgren, +8

PubMed

Tumor BiologyBreast OncologyOncologyCi1033 AccumulationGlioma +13

Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines.

G L Scheffer, Marc Maliepaard, A C Pijnenborg, +10

PubMed

Breast OncologyImmunologyPathologyTumor CellsImmunotherapy +15

Multidrug resistance related molecules in human and murine lung

G L Scheffer, A C Pijnenborg, Egbert F. Smit, +6

Journal of Clinical Pathology

Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma.

Hjg Arts, D Katsaros, Elisabeth G.E. de Vries, +10

PubMed

Prognostic FactorsPrognostic BiomarkersLung Resistance ProteinEarly StageMrp1 Expression +13

The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification.

ML Slovak, J. Pelkey Ho, Susan P.C. Cole, +6

PubMed

Gene AmplificationGeneticsGenomic MechanismMolecular BiologyPathology +18

A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line.

Paola Perego, Michelandrea De Cesare, P De Isabella, +10

PubMed

Health SciencesMedicinePharmacologyImmunologyCancer Cell Biology +12

Membrane transport proteins associated with drug resistance expressed in human melanoma.

Dirk Schadendorf, A Makki, C Stahr, +6

PubMed