RN486, a Selective Bruton's Tyrosine Kinase Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis in Rodents

Daigen Xu, Yong Kim, Jennifer Postelnek, +17

Journal of Pharmacology and Experimental Therapeutics

Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand

Michael Coronado, Giovanni Fajardo, Kim Nguyen, +9

Circulation Research

Dynamic microRNA expression during the transition from right ventricular hypertrophy to failure

Sushma Reddy, Mingming Zhao, Dong‐Qing Hu, +6

Physiological Genomics

Heart FailureRight Ventricular HypertrophyCongenital Heart AnomalyEpigeneticsDiastolic Function +15

Physiologic and molecular characterization of a murine model of right ventricular volume overload

Sushma Reddy, Mingming Zhao, Dong‐Qing Hu, +6

American Journal of Physiology-Heart and Circulatory Physiology

3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models

Michael Soth, Johannes C. Hermann, Calvin Yee, +36

Journal of Medicinal Chemistry

Drug TargetJanus KinasesImmunologyCellular PharmacologyPharmacotherapy +19

Time‐dependent evolution of functional <i>vs.</i> remodeling signaling in induced pluripotent stem cell‐derived cardiomyocytes and induced maturation with biomechanical stimulation

Gwanghyun Jung, Giovanni Fajardo, Alexandre J. S. Ribeiro, +11

The FASEB Journal

Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy

Cheng Liao, Jonathan Hsu, Yong Kim, +16

Arthritis Research & Therapy

Deletion of the β2-adrenergic receptor prevents the development of cardiomyopathy in mice

Giovanni Fajardo, Mingming Zhao, Takashi Urashima, +4

Journal of Molecular and Cellular Cardiology

Molecular PharmacologyCardiomyopathyHeart FailureMolecular PhysiologyMedicine +7

miR-21 is associated with fibrosis and right ventricular failure

Sushma Reddy, Dong‐Qing Hu, Mingming Zhao, +8

JCI Insight

Heart FailurePathologyCardiac RegenerationCongenital Heart AnomalyDiastolic Function +17

Transcriptomic and Functional Analyses of Mitochondrial Dysfunction in Pressure Overload‐Induced Right Ventricular Failure

HyunTae V. Hwang, Nefthi Sandeep, Ramesh V. Nair, +7

Journal of the American Heart Association