MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

Douglas D. Fang, Qiuqiong Tang, Yanhui Kong, +8

Journal for ImmunoTherapy of Cancer

Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways

Hongqian Chu, Qiuqiong Tang, Hongpeng Huang, +2

Environmental Toxicology and Pharmacology

InflammationCytokineAnti-inflammatoryMedicineImmunology +9

A plasma metabolite panel as biomarkers for early primary breast cancer detection

Baowen Yuan, Simon Schafferer, Qiuqiong Tang, +11

International Journal of Cancer

MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia models

Douglas D. Fang, Qiuqiong Tang, Yanhui Kong, +10

Cell Death Discovery

Let-7g is involved in doxorubicin induced myocardial injury

Jun Fu, Cike Peng, Wanyi Wang, +3

Environmental Toxicology and Pharmacology

InflammationHeart FailureMedicineCardiovascular PharmacologyPharmacotherapy +5

DNA methylation array analysis identifies breast cancer associated <i>RPTOR</i>, <i>MGRN1</i> and <i>RAPSN</i> hypomethylation in peripheral blood DNA

Qiuqiong Tang, Tim Holland‐Letz, Alla Slynko, +18

Oncotarget

FLT3 inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor lisaftoclax (APG-2575) in preclinical models of FLT3-ITD mutant acute myeloid leukemia

Douglas D. Fang, Hengrui Zhu, Qiuqiong Tang, +6

Translational Oncology

Evaluation of Promoter Methylation of RASSF1A and ATM in Peripheral Blood of Breast Cancer Patients and Healthy Control Individuals

Xue Cao, Qiuqiong Tang, Tim Holland‐Letz, +8

International Journal of Molecular Sciences

MAP4K4 deletion inhibits proliferation and activation of CD4+ T cell and promotes T regulatory cell generation in vitro

Hongpeng Huang, Qiuqiong Tang, Hongqian Chu, +4

Cellular Immunology

Signal TransductionCell RegulationT-regulatory CellImmunologyCd4+ T Cell +7

Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors

Xuechao Liu, Guangfeng Wang, Xianglei Yan, +13

Cell & Bioscience