Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment

Mitchell E. Horwitz, Nelson J. Chao, David A. Rizzieri, +20

Journal of Clinical Investigation

Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment

Tony Peled, Hadas Shoham, Dorit Aschengrau, +8

Experimental Hematology

Cell TherapyMarrow TransplantationMedicineImmunologyHematology +7

Omidubicel vs standard myeloablative umbilical cord blood transplantation: results of a phase 3 randomized study

Mitchell E. Horwitz, Patrick J. Stiff, Corey Cutler, +22

Blood

Cellular copper content modulates differentiation and self‐renewal in cultures of cord blood‐derived CD34⁺ cells

Tony Peled, Efrat Landau, Eugenia Prus, +2

British Journal of Haematology

Self‐renewal and commitment to differentiation of human leukemic promyelocytic cells (HL‐60)

Eitan Fibach, Tony Peled, Eliezer A. Rachmilewitz

Journal of Cellular Physiology

Modulation of the maturation of human leukemic promyelocytes (HL-60) to granulocytes or macrophages

Eitan Fibach, Tony Peled, Aliza Treves, +2

Leukemia Research

Developmental BiologyGranulocyteImmunologyHematologyBlood Cell +7

Cohort-Controlled Comparison of Umbilical Cord Blood Transplantation Using Carlecortemcel-L, a Single Progenitor–Enriched Cord Blood, to Double Cord Blood Unit Transplantation

Patrick J. Stiff, Pau Montesinos, Tony Peled, +23

Biology of Blood and Marrow Transplantation

StemEx®(Copper Chelation Based) Ex Vivo Expanded Umbilical Cord Blood Stem Cell Transplantation (UCBT) Accelerates Engraftment and Improves 100 Day Survival In Myeloablated Patients Compared To a Registry Cohort Undergoing Double Unit UCBT: Results Of a Multicenter Study Of 101 Patients With Hematologic Malignancies

Patrick J. Stiff, Pau Montesinos, Tony Peled, +22

Blood

Nicotinamide, a Form of Vitamin B3, Promotes Expansion of Natural Killer Cells That Display Increased In Vivo Survival and Cytotoxic Activity,

Gabi Frei, Nurit Persi, Chana Lador, +4

Blood

First-in-Human Phase I Study of Nicotinamide-Expanded Related Donor Natural Killer Cells for the Treatment of Relapsed/Refractory Non-Hodgkin Lymphoma and Multiple Myeloma

Veronika Bachanová, David H. McKenna, Xianghua Luo, +7

Biology of Blood and Marrow Transplantation

Cell TherapyRefractory NhlFirst-in-human PhaseImmunologyImmune Regulation +25