A Comparative In Vitro and In Vivo Pharmacological Characterization of the Novel Dopamine D3Receptor Antagonists (+)-S 14297, Nafadotride, GR 103,691 and U 99194

Valérie Audinot, Adrian Newman‐Tancredi, Alain P. Gobert, +8

Journal of Pharmacology and Experimental Therapeutics

S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D3-Receptors: I. Receptorial, Electrophysiological and Neurochemical Profile Compared with GR218,231 and L741,626

Mark J. Millan, Alain P. Gobert, Adrian Newman‐Tancredi, +6

Journal of Pharmacology and Experimental Therapeutics

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

Anne Dekeyne, Clotilde Mannoury la Cour, Alain P. Gobert, +13

Psychopharmacology

PsychiatryFunctional SelectivityMedicineAnxiolytic PropertiesDepression +10

S 18126 ({2-[4-(2,3-dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl methyl]indan-2-yl}), a Potent, Selective and Competitive Antagonist at Dopamine D4 Receptors: An In Vitro and In Vivo Comparison with L 745,870 (3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2,3b]pyridine) and Raclopride

Mark J. Millan, Adrian Newman‐Tancredi, Mauricette Brocco, +9

Journal of Pharmacology and Experimental Therapeutics

Activation of dopamine D3 autoreceptors inhibits firing of ventral tegmental dopaminergic neurones in vivo

Franćoise Lejeune, Mark J. Millan

European Journal of Pharmacology

Neurobiological MechanismNeuroanatomyDopamine D3 AutoreceptorsNeurotransmitterNeuropharmacology +9

Selective blockade of neurokinin (NK)₁ receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats

Mark J. Millan, Franćoise Lejeune, Guillaume De Nanteuil, +1

Journal of Neurochemistry

Selective NkSynaptic TransmissionNeurotransmitterReceptor AntagonistExperimental Pharmacology +17

Clozapine inhibits serotoninergic transmission by an action at α1-adrenoceptors not at 5-HT1A receptors

Franćoise Lejeune, Valérie Audinot, Alain P. Gobert, +3

European Journal of Pharmacology

Molecular PharmacologySerotoninergic TransmissionMedicinePsychotropic Medication5-Ht1a Receptors +7

S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist at presynaptic and postsynaptic sites respectively

Mark J. Millan, Jean‐Michel Rivet, Hervé Canton, +6

European Journal of Pharmacology

Functional SelectivityMedicinePostsynaptic SitesMolecular BiologyMechanism Of Action +5

S 14506: A novel, potent, high‐efficacy 5‐HT_1A agonist and potential anxiolytic agent

Françis C. Colpaert, Wouter Koek, John Lehmann, +7

Drug Development Research

Potential Anxiolytic AgentPharmacotherapyHigh‐efficacy 5‐HtSystem PharmacologyExperimental Pharmacology +15

WAY 100,135 and (−)-tertatolol act as antagonists at both 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors in vivo

Franćoise Lejeune, Jean‐Michel Rivet, Alain P. Gobert, +2

European Journal of Pharmacology

Signal TransductionMedicineSynaptic TransmissionPhysiology5-Ht1a Autoreceptors +11