Suoyu Xu

Discovery of <i>N</i>-[(1<i>S</i>,2<i>S</i>)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Linus S. Lin, Thomas J. Lanza, James P. Jewell et al. · Journal of Medicinal Chemistry · 2006 · 122 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1 S,2 S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents

Tung M. Fong, Xiao-Ming Guan, Donald J. Marsh et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 101 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Biphenyl-Substituted Oxazolidinones as Cholesteryl Ester Transfer Protein Inhibitors: Modifications of the Oxazolidinone Ring Leading to the Discovery of Anacetrapib

Cameron J. Smith, Amjad Ali, Milton L. Hammond et al. · Journal of Medicinal Chemistry · 2011 · 70 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors

Hong C. Shen, Fa‐Xiang Ding, Siyi Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement

Hong C. Shen, Fa‐Xiang Ding, Siyi Wang et al. · Journal of Medicinal Chemistry · 2009 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14