Shiang-Yuan Chen

Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans

Nirmala Raghavan, Charles Frost, Zhigang Yu et al. · Drug Metabolism and Disposition · 2008 · 604 citations

Pharmacy, Pharmacokinetics, Pharmacology +10

In Vitro Assessment of Metabolic Drug-Drug Interaction Potential of Apixaban through Cytochrome P450 Phenotyping, Inhibition, and Induction Studies

Lifei Wang, Donglu Zhang, Nirmala Raghavan et al. · Drug Metabolism and Disposition · 2009 · 252 citations

Medicine, Pharmacokinetics, Pharmacology +17

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

Donglu Zhang, Nirmala Raghavan, Shiang-Yuan Chen et al. · Drug Metabolism and Disposition · 2007 · 56 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Bioactivation of Benzylamine to Reactive Intermediates in Rodents:  Formation of Glutathione, Glutamate, and Peptide Conjugates

Abdul Mutlib, Patricia Dickenson, Shiang-Yuan Chen et al. · Chemical Research in Toxicology · 2002 · 34 citations

Medicine, Pharmacology, Drug Metabolism +15

Disposition of 1-[3-(Aminomethyl)phenyl]-<i>N</i>-[3-fluoro-2‘- (methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)- 1<i>H</i>-pyrazole-5-carboxamide (DPC 423) by Novel Metabolic Pathways. Characterization of Unusual Metabolites by Liquid Chromatography/Mass Spectrometry and NMR

Abdul Mutlib, John P. Shockcor, Shiang-Yuan Chen et al. · Chemical Research in Toxicology · 2001 · 32 citations

Medicine, Pharmacokinetics, Pharmacology +14