René JA de Bruin

Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor

Wendy W. Batenburg, Manne Krop, Ingrid M. Garrelds et al. · Journal of Hypertension · 2007 · 224 citations

Life Sciences, Pharmacology, Physiology +13

Clinical validation of renin monoclonal antibody-based sandwich assays of renin and prorenin, and use of renin inhibitor to enhance prorenin immunoreactivity

F. H. M. Derkx, René JA de Bruin, Jeanette M. van Gool et al. · Clinical Chemistry · 1996 · 67 citations · Full text

Pharmacy, Biochemistry, Pharmacology +13

Different contributions of the angiotensin-converting enzyme C-domain and N-domain in subjects with the angiotensin-converting enzyme II and DD genotype

Joep HM van Esch, Jeanette MG van Gool, René JA de Bruin et al. · Journal of Hypertension · 2008 · 15 citations

Medicine, Pharmacology, Biochemical Pharmacology +6

Activation of the immune system of cancer patients by continuous i.v. recombinant IL-2 (rIL-2) therapy is dependent on dose and schedule of rIL-2

Jan W. Gratama, René JA de Bruin, C. B. H. W. Lamers et al. · Clinical & Experimental Immunology · 1993 · 13 citations

Life Sciences, Immunology, Oncology +10

Atrial wall stress rather than pressure per se might be responsible for the increased secretion of atrial natriuretic factor after heart transplantation

René M.L. Brouwer, G J Wenting, Felix Zijlstra et al. · Journal of Hypertension · 1988 · 11 citations

Medicine, Cardiology, Physiology +9