Alternative myosin hinge regions are utilized in a tissue-specific fashion that correlates with muscle contraction speed.

V L Collier, William A. Kronert, P T O'Donnell, +2

Genes & Development

Muscle FunctionGeneticsGenomic MechanismCytoskeletonMechanotransduction +23

Myosin Transducer Mutations Differentially Affect Motor Function, Myofibril Structure, and the Performance of Skeletal and Cardiac Muscles

Anthony Cammarato, Corey M. Dambacher, Aileen F. Knowles, +4

Molecular Biology of the Cell

Cardiac MuscleMuscle FunctionCytoskeletonMechanotransductionCardiac Muscles +20

Defects in theDrosophilaMyosin Rod Permit Sarcomere Assembly but Cause Flight Muscle Degeneration

William A. Kronert, P T O'Donnell, Annabeth Fieck, +4

Journal of Molecular Biology

MechanobiologyBiologyMuscle FunctionDevelopmental BiologySkeletal Muscle +9

Analysis of the 5' end of the Drosophila muscle myosin heavy chain gene. Alternatively spliced transcripts initiate at a single site and intron locations are conserved compared to myosin genes of other organisms.

D R Wassenberg, William A. Kronert, P T O'Donnell, +1

Journal of Biological Chemistry

Transformation of Drosophila melanogaster with the wild-type myosin heavy-chain gene: rescue of mutant phenotypes and analysis of defects caused by overexpression.

Richard M. Cripps, Kathrin Becker, Maibritt Mardahl, +3

The Journal of Cell Biology

GeneticsGenomic MechanismMolecular GeneticsCytoskeletonCellular Physiology +16

<i>Drosophila</i>UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability

Chi F. Lee, Girish C. Melkani, Qin Yu, +6

Journal of Cell Science

Muscle FunctionGeneticsMolecular GeneticsCytoskeletonCellular Physiology +19

Alternative N-Terminal Regions of Drosophila Myosin Heavy Chain Tune Muscle Kinetics for Optimal Power Output

Douglas M. Swank, William A. Kronert, Sanford I. Bernstein, +1

Biophysical Journal

BiologyOptimal Power OutputMuscle FunctionEngineeringAlternative N-terminal Regions +8

Altered turnover of allelic variants of hypoxanthine phosphoribosyltransferase is associated with N-terminal amino acid sequence variation.

G. G. Johnson, William A. Kronert, Sanford I. Bernstein, +2

Journal of Biological Chemistry

Hprt AGeneticsHuman PolymorphismHprt BMolecular Biology +19

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy

Viola Kooij, Meera Viswanathan, Dong I. Lee, +8

Cardiovascular Research

Muscle-specific accumulation of Drosophila myosin heavy chains: a splicing mutation in an alternative exon results in an isoform substitution.

William A. Kronert, Kevin A. Edwards, E.S. Roche, +2

The EMBO Journal

BiologyMolecular PhysiologyIsoform SubstitutionSkeletal MuscleMedicine +10