Tiancen Hu

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Julien P. N. Papillon, Katsumasa Nakajima, Christopher D. Adair et al. · Journal of Medicinal Chemistry · 2018 · 237 citations · Full text

Medicine, Cancer Biology, Oncology +11

Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies

Patrick Schöffski, Daniel Shao-Weng Tan, Miguel Martín et al. · Journal for ImmunoTherapy of Cancer · 2022 · 156 citations · Full text

Medicine, Oncology, Pharmacology +17

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin

Lei Ji, Bo Lü, Raffaella Zamponi et al. · Nature Communications · 2019 · 126 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure

Tiancen Hu, Yu Zhang, Lianwei Li et al. · Virology · 2009 · 120 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease

Shuai Chen, Tiancen Hu, Jian Zhang et al. · Journal of Biological Chemistry · 2007 · 95 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16