Mie Fabricius Pedersen

Structural insights into differences in G protein activation by family A and family B GPCRs

Daniel Hilger, Kaavya Krishna Kumar, Hongli Hu et al. · Science · 2020 · 160 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors

M Gabe, Alexander H. Sparre‐Ulrich, Mie Fabricius Pedersen et al. · Biochemical Pharmacology · 2018 · 101 citations

Life Sciences, Molecular Biology, Pharmacology +13

Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics

Mie Fabricius Pedersen, Tomasz M. Wróbel, Emil Märcher-Rørsted et al. · Neuropharmacology · 2019 · 80 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

Thor C. Møller, Mie Fabricius Pedersen, Jeffrey R. van Senten et al. · Scientific Reports · 2020 · 56 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Characterization of the real-time internalization of nine GPCRs reveals distinct dependence on arrestins and G proteins

Thor C. Møller, Ee Von Moo, Asuka Inoue et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2023 · 16 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17