Jaimin K. Rana

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

Ciric To, Tyler S. Beyett, Jaebong Jang et al. · Nature Cancer · 2022 · 161 citations · Full text

Medicine, Oncology, Pharmacology +15

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

Tyler S. Beyett, Ciric To, David E. Heppner et al. · Nature Communications · 2022 · 84 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Design of a “Two-in-One” Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

Florian Wittlinger, David E. Heppner, Ciric To et al. · Journal of Medicinal Chemistry · 2021 · 43 citations · Full text

Pharmacy, Oncology, Pharmacology +17

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19

Jennifer Alisa Amrhein, Tyler S. Beyett, William W. Feng et al. · Journal of Medicinal Chemistry · 2022 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Structural Analysis of the Macrocyclic Inhibitor BI‐4020 Binding to EGFR Kinase

Tyler S. Beyett, Jaimin K. Rana, Ilse K. Schaeffner et al. · ChemMedChem · 2024 · 10 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14