Currently, biomarkers that predict the efficacy of everolimus in metastatic renal cell carcinoma (mRCC) patients are lacking. Everolimus inhibits vascular endothelial growth factor A (VEGF-A) expression. We performed PET scans on mRCC patients with ⁸⁹Zr-bevacizumab, a VEGF-A-binding antibody tracer. The aims were to determine a change in tumor tracer uptake after the start of everolimus and to explore whether ⁸⁹Zr-bevacizumab PET can identify patients with early disease progression. Methods:⁸⁹Zr-bevacizumab PET was done before and 2 and 6 wk after the start of everolimus, 10 mg/d, in mRCC patients. Routine CT scans were performed at baseline and every 3 mo thereafter. Tumor tracer uptake was quantified using SUV_max The endpoints were a change in tumor tracer uptake and treatment response on CT after 3 mo. Results: Thirteen patients participated. The median SUV_max of 94 tumor lesions was 7.3 (range, 1.6-59.5). Between patients, median tumor SUV_max varied up to 8-fold. After 2 wk, median SUV_max was 6.3 (1.7-62.3), corresponding to a mean decrease of 9.1% (P < 0.0001). Three patients discontinued everolimus early. At 6 wk, a mean decrease in SUV_max of 23.4% compared with baseline was found in 70 evaluable lesions of 10 patients, with a median SUV_max of 5.4 (1.1-49.4, P < 0.0001). All 10 patients who continued treatment had stable disease at 3 mo. Conclusion: Everolimus decreases ⁸⁹Zr-bevacizumab tumor uptake. Further studies are warranted to evaluate the predictive value of ⁸⁹Zr-bevacizumab PET for everolimus antitumor efficacy.

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