Jessica A. Castrillon

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

Constantia Pantelidou, Olmo Sonzogni, Mateus de Oliveira Taveira et al. · Cancer Discovery · 2019 · 720 citations · Full text

Medicine, Immunology, Oncology +17

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

Jennifer L. Guerriero, Alaba Sotayo, Holly Ponichtera et al. · Nature · 2017 · 551 citations · Full text

Medicine, Oncology, Pharmacology +12

Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer

Anita K. Mehta, Emily Cheney, Christina Hartl et al. · Nature Cancer · 2020 · 259 citations · Full text

Medicine, Immunology, Oncology +16

Comprehensive characterization of protein–protein interactions perturbed by disease mutations

Feixiong Cheng, Junfei Zhao, Yang Wang et al. · Nature Genetics · 2021 · 248 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer

Dennis O. Adeegbe, Yan Liu, Patrick H. Lizotte et al. · Cancer Discovery · 2017 · 150 citations · Full text

Medicine, Immunology, Oncology +17