CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant

Hiroshi Sakamoto, Toshiyuki Tsukaguchi, Sayuri Hiroshima, +7

Cancer Cell

Molecular PharmacologyResistant Gatekeeper MutantDrug DiscoveryNatural SciencesMechanism Of Action +6

Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells

Aikou Okamoto, Takashi Nikaido, Kazunori Ochiai, +11

Clinical Cancer Research

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy

Hiroshi Sakamoto, Koichi Okamoto, Masahiro Aoki, +9

Nature Chemical Biology

BiochemistrySynthetic VirologyViral HepatitisPathogenesisImmunology +4

Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Nobuya Ishii, Naoki Harada, Eric W. Joseph, +15

Cancer Research

Raf Feedback LimitsRaf ActivityCancer BiologyTumor BiologySignaling Pathway +15

Tetracycline-Regulatable System To Tightly Control Gene Expression in the Pathogenic Fungus <i>Candida albicans</i>

Hironobu Nakayama, Toshiyuki Mio, Shigehisa Nagahashi, +3

Infection and Immunity

Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors

Satoshi Sogabe, Miyako Masubuchi, Kiyoaki Sakata, +11

Chemistry & Biology

Antifungal AgentBiochemistryNatural SciencesMolecular BiologyYeast +2

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

Miyako Masubuchi, Hirosato Ebiike, Ken‐ichi Kawasaki, +11

Bioorganic & Medicinal Chemistry

BiosynthesisAntifungal AgentBiochemistryBenzofuran Antifungal AgentsAntifungal Agents +6

The Fibroblast Growth Factor Receptor Genetic Status as a Potential Predictor of the Sensitivity to CH5183284/Debio 1347, a Novel Selective FGFR Inhibitor

Yoshito Nakanishi, Nukinori Akiyama, Toshiyuki Tsukaguchi, +11

Molecular Cancer Therapeutics

Radiation OncologyFgf ReceptorsNovel TherapyFgfr EnzymesMedicine +11

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N -myristoyltransferase. Part 1

Miyako Masubuchi, Ken‐ichi Kawasaki, Hirosato Ebiike, +9

Bioorganic & Medicinal Chemistry Letters

BiosynthesisBioorganic ChemistryPart 1EngineeringAntifungal Agent +9

<i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-Tetraalkyl-2,2′-dihydroxy-1,1′-binaphthyl-3,3′-dicarboxamides: Novel Chiral Auxiliaries for Asymmetric Simmons–Smith Cyclopropanation of Allylic Alcohols and for Asymmetric Diethylzinc Addition to Aldehydes

Hiroshi Kitajima, Katsuji Ito, Yuko Aoki, +1

Bulletin of the Chemical Society of Japan

Enantioselective SynthesisDerivativesAsymmetric AdditionBiochemistryEngineering +13