Karine Lafleur

Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis

Danzhi Huang, Ting Zhou, Karine Lafleur et al. · Bioinformatics · 2009 · 141 citations · Full text

Structure-Based Optimization of Potent and Selective Inhibitors of the Tyrosine Kinase Erythropoietin Producing Human Hepatocellular Carcinoma Receptor B4 (EphB4)

Karine Lafleur, Danzhi Huang, Ting Zhou et al. · Journal of Medicinal Chemistry · 2009 · 94 citations · Full text

Drug Target, Structure-based Optimization, Selective Inhibitors +18

Discovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular Dynamics

Hongtao Zhao, Jing Dong, Karine Lafleur et al. · ACS Medicinal Chemistry Letters · 2012 · 49 citations · Full text

Drug Target, Engineering, Molecular Biology +22

Pyrrolo[3,2-<i>b</i>]quinoxaline Derivatives as Types I_1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and <i>in Vivo</i> Validation

Andrea Unzue, Jing Dong, Karine Lafleur et al. · Journal of Medicinal Chemistry · 2014 · 31 citations · Full text

Crystal Structure, Catalytic Domain, Heterocycle Chemistry +20

Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography

Karine Lafleur, Jing Dong, Danzhi Huang et al. · Journal of Medicinal Chemistry · 2012 · 27 citations · Full text

X-ray Crystallography, Cellular Potency Improvement, Molecular Biology +19