Søren Ottosen

<i>In Vitro</i> Antiviral Activity and Preclinical and Clinical Resistance Profile of Miravirsen, a Novel Anti-Hepatitis C Virus Therapeutic Targeting the Human Factor miR-122

Søren Ottosen, Todd B. Parsley, Lu Yang et al. · Antimicrobial Agents and Chemotherapy · 2014 · 230 citations · Full text

Pharmacy, Infectious Diseases, Pharmacotherapy +15

Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1

Shahram Misaghi, Søren Ottosen, Anita Izrael-Tomasevic et al. · Molecular and Cellular Biology · 2009 · 216 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies

Jeffrey N. Savas, Anthony J. Makusky, Søren Ottosen et al. · Proceedings of the National Academy of Sciences · 2008 · 162 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Miravirsen dosing in chronic hepatitis C patients results in decreased micro<scp>RNA</scp>‐122 levels without affecting other micro<scp>RNA</scp>s in plasma

Meike H. van der Ree, Ad C. van Nuenen, Joep de Bruijne et al. · Alimentary Pharmacology & Therapeutics · 2015 · 154 citations · Full text

Pharmacy, Infectious Diseases, Pharmacotherapy +14

Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern

Peter Hagedorn, Victor Yakimov, Søren Ottosen et al. · Nucleic Acid Therapeutics · 2013 · 97 citations · Full text

Pharmacy, Pharmacology, Toxicology +17