Piet Hein Van der Graaf

Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of the Effects of N6-Cyclopentyladenosine Analogs on Heart Rate in Rat: Estimation of in Vivo Operational Affinity and Efficacy at Adenosine A1 Receptors

Piet Hein Van der Graaf, E.A. van Schaick, Ron A. A. Mathôt et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 56 citations

Analysis of asymmetry of agonist concentration–effect curves

Piet Hein Van der Graaf, Rik C. Schoemaker · Journal of Pharmacological and Toxicological Methods · 1999 · 37 citations

Molecular Pharmacology, Agonist Concentration–effect Curves, Medicine +6

On the reliability of affinity and efficacy estimates obtained by direct operational model fitting of agonist concentration-effect curves following irreversible receptor inactivation

Piet Hein Van der Graaf, Meindert Danhof · Journal of Pharmacological and Toxicological Methods · 1997 · 19 citations

Agonist Concentration-effect Curves, Functional Selectivity, Medicine +9

Mechanism-Based Modeling of Functional Adaptation Upon Chronic Treatment with Midazolam

Adriaan Cleton, Jonas Ödman, Piet Hein Van der Graaf et al. · Pharmaceutical Research · 2000 · 16 citations

Analysis of receptor inactivation experiments with the operational model of agonism yields correlated estimates of agonist affinity and efficacy

Piet Hein Van der Graaf, Wiro B. Stam · Journal of Pharmacological and Toxicological Methods · 1999 · 15 citations

Signal Transduction, Operational Model, Medicine +12