J. Paul

Structure-Based Design and Discovery of Protein Tyrosine Phosphatase Inhibitors Incorporating Novel Isothiazolidinone Heterocyclic Phosphotyrosine Mimetics

Andrew P. Combs, Eddy W. Yue, Michael J. Bower et al. · Journal of Medicinal Chemistry · 2005 · 101 citations · Full text

Molecular Docking, Crystal Structure, Medicinal Chemistry +13

Molecular Basis of HIV-1 Protease Drug Resistance:  Structural Analysis of Mutant Proteases Complexed with Cyclic Urea Inhibitors

J. Paul, Edward E. Huston, Ronald M. Klabe et al. · Biochemistry · 1997 · 97 citations

Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic ( <i>S</i> )-Isothiazolidinone Phosphotyrosine Mimetic

Andrew P. Combs, Wenyu Zhu, Matthew L. Crawley et al. · Journal of Medicinal Chemistry · 2006 · 85 citations · Full text

Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics

J. Paul, Lucie Gonneville, Milton C. Hillman et al. · Journal of Biological Chemistry · 2006 · 83 citations · Full text

Resistance to HIV Protease Inhibitors:  A Comparison of Enzyme Inhibition and Antiviral Potency

Ronald M. Klabe, Lee T. Bacheler, J. Paul et al. · Biochemistry · 1998 · 80 citations