Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Kouichi Miura, Yuzo Kodama, Sayaka Inokuchi, +6

Gastroenterology

InflammationToll-like ReceptorsMolecular ImmunologyCytokineToll-like Receptor 9 +12

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Kouichi Miura, Ling Yang, Nico van Rooijen, +2

American Journal of Physiology-Gastrointestinal and Liver Physiology

Toll-Like Receptor 2 and Palmitic Acid Cooperatively Contribute to the Development of Nonalcoholic Steatohepatitis Through Inflammasome Activation in Mice

Kouichi Miura, Ling Yang, Nico van Rooijen, +3

Hepatology

Evidence That Zymogen Granules Are Not a Physiologically Relevant Calcium Pool

David I. Yule, Stephen A. Ernst, Hirohide Ohnishi, +1

Journal of Biological Chemistry

Protein SecretionInsp3 ReceptorsCytoskeletonOsteoporosisCellular Physiology +15

Impaired Production of Gastric Ghrelin in Chronic Gastritis Associated with<i>Helicobacter pylori</i>

Hiroyuki Osawa, Masamitsu Nakazato, Yukari Date, +7

The Journal of Clinical Endocrinology & Metabolism

NutritionImmunologyGastroenterologyDigestive TractGastrointestinal Peptide Hormone +17

Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease

Kouichi Miura, Ekihiro Seki, Hirohide Ohnishi, +1

Gastroenterology Research and Practice

Tlr LigandsInnate Immune SystemImmunologyTheir Downstream MoleculesInnate Immunity +21

Distinct Roles of Smad2-, Smad3-, and ERK-dependent Pathways in Transforming Growth Factor-β1 Regulation of Pancreatic Stellate Cellular Functions

Hirohide Ohnishi, Tomohiko Miyata, Hiroshi Yasuda, +10

Journal of Biological Chemistry

Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells

Hiroshi Yasuda, Shuko Hirata, Kazuaki Inoue, +3

Biochemical and Biophysical Research Communications

Bile Acid-induced ActivationSignal TransductionSignaling PathwayMitogen-activated Protein KinasesBiliary Tract +9

Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice

Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima, +11

Journal of Hepatology

Hepatocyte-specific Pten-deficient MiceHepatologyBiochemistryMedicineLiver Physiology +9

Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice.

Hirohide Ohnishi, Linda C. Samuelson, David I. Yule, +2

Journal of Clinical Investigation

Protein SecretionImmunologyTransgenic MiceCellular PhysiologyRegulated Amylase Secretion +19