We have previously predicted that the decrease in maximal oxygen uptake (V̇o_2max) that accompanies time in microgravity reflects decrements in both convective and diffusive O₂ transport to the mitochondria of the contracting myocytes. The aim of this investigation was therefore to quantify the relative changes in convective O₂ transport (Q̇o₂) and O₂ diffusing capacity (Do₂) following long-duration spaceflight. In nine astronauts, resting hemoglobin concentration ([Hb]), V̇o_2max, maximal cardiac output (Q̇_Tmax), and differences in arterial and venous O₂ contents ([Formula: see text]-[Formula: see text]) were obtained retrospectively for International Space Station Increments 19-33 (April 2009-November 2012). Q̇o₂ and Do₂ were calculated from these variables via integration of Fick's Principle of Mass Conservation and Fick's Law of Diffusion. V̇o_2max significantly decreased from pre- to postflight (-53.9 ± 45.5%, P = 0.008). The significant decrease in Q̇_Tmax (-7.8 ± 9.1%, P = 0.05), despite an unchanged [Hb], resulted in a significantly decreased Q̇o₂ (-11.4 ± 10.5%, P = 0.02). Do₂ significantly decreased from pre- to postflight by -27.5 ± 24.5% (P = 0.04), as did the peak [Formula: see text]-[Formula: see text] (-9.2 ± 7.5%, P = 0.007). With the use of linear regression analysis, changes in V̇o_2max were significantly correlated with changes in Do₂ (R² = 0.47; P = 0.04). These data suggest that spaceflight decreases both convective and diffusive O₂ transport. These results have practical implications for future long-duration space missions and highlight the need to resolve the specific mechanisms underlying these spaceflight-induced changes along the O₂ transport pathway.NEW & NOTEWORTHY Long-duration spaceflight elicited a significant decrease in maximal oxygen uptake. Given the adverse physiological adaptations to microgravity along the O₂ transport pathway that have been reported, an integrative approach to the determinants of postflight maximal oxygen uptake is needed. We demonstrate that both convective and diffusive oxygen transport are decreased following ~6 mo International Space Station missions.

#	Concept	H-Index	Publications	Citations
1	Engineering	1	1	19
2	Space Engineering	1	1	19
3	Chemical Kinetics	1	1	19

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