A. E. M. Holthuysen

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

Arjen B. Blom, Peter L. E. M. van Lent, A. E. M. Holthuysen et al. · Osteoarthritis and Cartilage · 2004 · 373 citations · Full text

Medicine, Cell Biology, Immunology +11

Crucial role of macrophages in matrix metalloproteinase–mediated cartilage destruction during experimental osteoarthritis : Involvement of matrix metalloproteinase 3

Arjen B. Blom, P.L. van Lent, Sten F.W.M. Libregts et al. · Arthritis & Rheumatism · 2006 · 361 citations

Medicine, Pathobiology, Pathology +17

Crucial role of synovial lining macrophages in the promotion of transforming growth factor β–mediated osteophyte formation

Peter L. E. M. van Lent, Arjen B. Blom, P. van der Kraan et al. · Arthritis & Rheumatism · 2004 · 193 citations

Medicine, Orthopedic Surgery, Pathobiology +15

Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis

Joyce B. J. van Meurs, Peter L. E. M. van Lent, A. E. M. Holthuysen et al. · Arthritis & Rheumatism · 1999 · 125 citations

Medicine, Pathobiology, Pathology +17

Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin 1 in matrix metalloproteinase activity

Joyce B. J. van Meurs, Peter van Lent, Reinout Stoop et al. · Arthritis & Rheumatism · 1999 · 114 citations

Medicine, Molecular Biology, Pathology +17