Mitchell C. Brenner

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

Xingnan Zheng, Bo Zhai, Peppi Koivunen et al. · Genes & Development · 2014 · 134 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

Inhibition of Collagen Synthesis With Prolyl 4-Hydroxylase Inhibitor Improves Left Ventricular Function and Alters the Pattern of Left Ventricular Dilatation After Myocardial Infarction

John I. Nwogu, David L. Geenen, Maurice Bean et al. · Circulation · 2001 · 129 citations

Medicine, Cardiology, Pharmacology +16

Transforming Growth Factor-β Induces Secretion of Activated ADAMTS-2

Wei-Man Wang, Seungbok Lee, Barry M. Steiglitz et al. · Journal of Biological Chemistry · 2003 · 107 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells

Tiina M. Asikainen, Aftab Ahmad, Barbara Schneider et al. · Free Radical Biology and Medicine · 2005 · 94 citations

Life Sciences, Biochemistry, Cell Biology +13

Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease

Ughetta del Balzo, Pierre Signore, Gail Walkinshaw et al. · Journal of Pharmacology and Experimental Therapeutics · 2020 · 65 citations · Full text

Medicine, Biochemistry, Hematology +16