Dorfin Ubiquitylates Mutant SOD1 and Prevents Mutant SOD1-mediated Neurotoxicity

Jun-ichi Niwa, Shinsuke Ishigaki, Nozomi Hishikawa, +6

Journal of Biological Chemistry

Protein FunctionMolecular NeuroscienceAmyotrophic Lateral SclerosisMotor NeuronsMedicine +9

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration

Yohei Iguchi, Masahisa Katsuno, Jun-ichi Niwa, +11

Brain

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisMolecular NeuroscienceSkeletal MuscleMotor Neurons +10

TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases

Yohei Iguchi, Masahisa Katsuno, Jun-ichi Niwa, +10

Journal of Biological Chemistry

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords – screening by molecular indexing and subsequent cDNA microarray analysis

Shinsuke Ishigaki, Jun-ichi Niwa, Tsuyoshi Yoshihara, +6

FEBS Letters

Neurochemical BiomarkersDisease Gene IdentificationGene Expression ProfilingUbiquitin-proteasome SystemSocial Sciences +16

A Novel Centrosomal RING-Finger Protein, Dorfin, Mediates Ubiquitin Ligase Activity

Jun-ichi Niwa, Shinsuke Ishigaki, Manabu Doyu, +3

Biochemical and Biophysical Research Communications

ChromatinProtein FunctionMolecular RegulationNatural SciencesMolecular Biology +6

Physical and Functional Interaction between Dorfin and Valosin-containing Protein That Are Colocalized in Ubiquitylated Inclusions in Neurodegenerative Disorders

Shinsuke Ishigaki, Nozomi Hishikawa, Jun-ichi Niwa, +6

Journal of Biological Chemistry

Functional InteractionMolecular BiologyDorfin-associated ProteinNeurochemical BiomarkersCytoskeleton +19

Dorfin Localizes to the Ubiquitylated Inclusions in Parkinson's Disease, Dementia with Lewy Bodies, Multiple System Atrophy, and Amyotrophic Lateral Sclerosis

Nozomi Hishikawa, Jun-ichi Niwa, Manabu Doyu, +4

American Journal Of Pathology

Amyotrophic Lateral SclerosisAlzheimer's DiseaseMultiple System AtrophyDegenerative DiseaseNeurology +7

Tuft-shaped astrocytes in Lewy body disease

Nozomi Hishikawa, Yoshio Hashizume, Mari Yoshida, +3

Acta Neuropathologica

PathologyTuft-shaped AstrocytesNeurologyNeuropathologyMedicine +1