Lucie Hyršová

Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors

Lucie Hyršová, Alena Vanduchova, Ján Dušek et al. · Toxicology Letters · 2018 · 44 citations

Food Chemistry, Polyphenolics, Other Natural Stilbenes +11

Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor

Alejandro Carazo, Lucie Hyršová, Ján Dušek et al. · Toxicology Letters · 2016 · 42 citations

Biochemistry, Medicine, Receptor (Biochemistry) +4

Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR)

Alejandro Carazo, Tomáš Smutný, Lucie Hyršová et al. · Toxicology Letters · 2015 · 40 citations

Biochemistry, Functional Selectivity, Medicine +9

The pregnane X receptor down‐regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC‐1 coactivator

Lucie Hyršová, Tomáš Smutný, Alejandro Carazo et al. · British Journal of Pharmacology · 2016 · 37 citations · Full text

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

Tomáš Smutný, Ján Dušek, Lucie Hyršová et al. · Acta Pharmaceutica Sinica B · 2019 · 25 citations · Full text