Patrick Horne

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Christopher Janus, Jacqueline Pearson, JoAnne McLaurin et al. · Nature · 2000 · 1.4K citations

Neurodegenerative Diseases, Alzheimer's Disease, Medicine +10

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

M. Azhar Chishti, Dun-Shen Yang, Christopher Janus et al. · Journal of Biological Chemistry · 2001 · 947 citations · Full text

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

Raymond H. Kim, Patrice D. Smith, Hossein Aleyasin et al. · Proceedings of the National Academy of Sciences · 2005 · 702 citations · Full text

Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis

JoAnne McLaurin, Roxana Cecal, Meredith E. Kierstead et al. · Nature Medicine · 2002 · 411 citations

Alzheimer's Disease, Medicine, Peptide Engineering +9

<i>In vivo</i> reduction of amyloid-β by a mutant copper transporter

Amie L. Phinney, Bettina Drisaldi, Stephen D. Schmidt et al. · Proceedings of the National Academy of Sciences · 2003 · 202 citations · Full text