Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Matthew Volgraf, Benjamin D. Sellers, Yu Jiang, +29

Journal of Medicinal Chemistry

Synaptic TransmissionNeurotransmitterSynaptic SignalingSocial SciencesMolecular Pharmacology +26

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Jack A. Terrett, Huifen Chen, Daniel G. Shore, +36

Journal of Medicinal Chemistry

Novel hexacyclic camptothecin derivatives. Part 1: Synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring

Sheng Wang, Yuyan Li, Yonghui Liu, +2

Bioorganic & Medicinal Chemistry Letters

EngineeringBioorganic ChemistryHeterocyclicOrganic ChemistryHeterocycle Chemistry +3

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved <i>in Vivo</i> Profile

Elisia Villemure, Matthew Volgraf, Yu Jiang, +19

ACS Medicinal Chemistry Letters

Discovery of a Potent (4<i>R</i>,5<i>S</i>)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Huifen Chen, Matthew Volgraf, Steven Do, +27

Journal of Medicinal Chemistry

Drug TargetMolecular PainPharmacotherapyPharmacodynamic ModelingMolecular Pharmacology +16

Synthesis, in Vitro and in Vivo Biological Evaluation, Docking Studies, and Structure−Activity Relationship (SAR) Discussion of Dipeptidyl Boronic Acid Proteasome Inhibitors Composed of β-Amino Acids

Yongqiang Zhu, Xinrong Zhu, Gang Wu, +12

Journal of Medicinal Chemistry

Antiparasitic AgentPharmacotherapyChemical BiologyPharmaceutical ChemistryIsomer 4P +17

Novel N-phenyl dichloroacetamide derivatives as anticancer reagents: Design, synthesis and biological evaluation

Yong-Chong Yang, Pei‐Hua Shang, Changmei Cheng, +6

European Journal of Medicinal Chemistry

Medicinal ChemistryDerivative (Chemistry)MedicineChemical DerivativeAnticancer Reagents +6

3D-QSAR studies of boron-containing dipeptides as proteasome inhibitors with CoMFA and CoMSIA methods

Yongqiang Zhu, Meng Lei, Aijun Lu, +3

European Journal of Medicinal Chemistry

Molecular DockingMedicinal ChemistryBiochemistryComsia MethodsNatural Sciences +7

3D-QSAR study of 20 (S)-camptothecin analogs

Aijun Lu, Zhenshan Zhang, Mingyue Zheng, +3

Acta Pharmacologica Sinica

Medicinal ChemistryMedicine3D-qsar StudyRational Drug DesignDrug Development +2

Design, synthesis and docking studies on benzamide derivatives as histone deacetylase inhibitors

Aijun Lu, Hongpeng Luo, Minfeng Shi, +4

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryDerivative (Chemistry)BiochemistryBenzamide Derivatives +8