Aijun Lu

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

Matthew Volgraf, Benjamin D. Sellers, Yu Jiang et al. · Journal of Medicinal Chemistry · 2016 · 102 citations · Full text

Synaptic Transmission, Neurotransmitter, Synaptic Signaling +28

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy

Jack A. Terrett, Huifen Chen, Daniel G. Shore et al. · Journal of Medicinal Chemistry · 2021 · 49 citations · Full text

Novel hexacyclic camptothecin derivatives. Part 1: Synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring

Sheng Wang, Yuyan Li, Yonghui Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 39 citations

Engineering, Bioorganic Chemistry, Heterocyclic +5

GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved <i>in Vivo</i> Profile

Elisia Villemure, Matthew Volgraf, Yu Jiang et al. · ACS Medicinal Chemistry Letters · 2016 · 39 citations · Full text

Discovery of a Potent (4<i>R</i>,5<i>S</i>)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Huifen Chen, Matthew Volgraf, Steven Do et al. · Journal of Medicinal Chemistry · 2018 · 39 citations · Full text

Drug Target, Molecular Pain, Pharmacotherapy +18