Matthew M. Hutmacher

Efficient Screening of Covariates in Population Models Using Wald's Approximation to the Likelihood Ratio Test

Kenneth G. Kowalski, Matthew M. Hutmacher · Journal of Pharmacokinetics and Pharmacodynamics · 2001 · 66 citations

Exposure-response modeling using latent variables for the efficacy of a JAK3 inhibitor administered to rheumatoid arthritis patients

Matthew M. Hutmacher, Sriram Krishnaswami, Kenneth G. Kowalski · Journal of Pharmacokinetics and Pharmacodynamics · 2007 · 61 citations

Rheumatoid Disorder, Rheumatology, Autoimmune Disease +8

Design evaluation for a population pharmacokinetic study using clinical trial simulations: a case study

Kenneth G. Kowalski, Matthew M. Hutmacher · Statistics in Medicine · 2000 · 60 citations · Full text

Sample Size Requirements, Clinical Trial Simulations, Sparse Sampling Design +15

Changes in serum creatinine in patients with active rheumatoid arthritis treated with tofacitinib: results from clinical trials

John D. Isaacs, Andrea Zuckerman, Sriram Krishnaswami et al. · Arthritis Research & Therapy · 2014 · 50 citations · Full text

Performance Characteristics for Some Typical QT Study Designs Under the ICH E‐14 Guidance

Matthew M. Hutmacher, Sunny Chapel, Marilyn A. Agin et al. · The Journal of Clinical Pharmacology · 2008 · 44 citations

Engineering, Measurement, Medicine +11