Mutations in GDI1 are responsible for X-linked non-specific mental retardation

Patrizia D’Adamo, Andrea Menegon, Cristiana Lo Nigro, +12

Nature Genetics

Mendelian DisorderPsychiatryGenetic DisorderGeneticsPsychiatric Genetics +5

Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations

Agnès Petit-Paitel, Toshitaka Kawarai, Erwan Paitel, +13

Journal of Biological Chemistry

MitophagyParkinson Disease-related MutationsCell DeathMolecular BiologyCytochrome C Release +15

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

Janin Lautenschläger, Amberley D. Stephens, Giuliana Fusco, +17

Nature Communications

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity

Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt‐Ulms, +17

Nature

Protein SecretionSignal Transductionɛ-Secretase ActivityMedicineNatural Sciences +7

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP

M. Emdadul Haque, Kelly Jean Thomas Craig, Cheryl D’Souza, +7

Proceedings of the National Academy of Sciences

MitophagyMitochondrial FunctionAutophagyMolecular BiologyCell Death +10

Analysis of the PINK1 Gene in a Large Cohort of Cases With Parkinson Disease

Ekaterina Rogaeva, Janel Johnson, Anthony E. Lang, +22

Archives of Neurology

Structure and mutational analysis of Rab GDP-dissociation inhibitor

Isabella Schalk, Ke Zeng, Shih-Kwang Wu, +6

Nature

Molecular BiologyMutagenesisRab Gdp-dissociation Inhibitor

Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins

Dun-Sheng Yang, Anurag Tandon, Fusheng Chen, +13

Journal of Biological Chemistry

APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes

Yongjun Gu, Fusheng Chen, Nobuo Sanjo, +10

Journal of Biological Chemistry

Nicastrin binds to membrane-tethered Notch

Fusheng Chen, Gang Yu, Shigeki Arawaka, +16

Nature Cell Biology

Membrane StructureProteinlipid InteractionMolecular PhysiologySignal TransductionMembrane-tethered Notch +6