François Martin

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

François Ghiringhelli, Cédric Menard, Pierre E. Puig et al. · Cancer Immunology Immunotherapy · 2006 · 1.2K citations · Full text

Life Sciences, Immunology, Oncology +17

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

Julie Vincent, Grégoire Mignot, Fanny Chalmin et al. · Cancer Research · 2010 · 1.2K citations

Medicine, Immunology, Oncology +17

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

Fanny Chalmin, Sylvain Ladoire, Grégoire Mignot et al. · Journal of Clinical Investigation · 2010 · 987 citations · Full text

Medicine, Immunology, Oncology +16

CD4<b>+</b>CD25<b>+</b> regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

François Ghiringhelli, Cédric Menard, Magali Terme et al. · The Journal of Experimental Medicine · 2005 · 919 citations · Full text

Life Sciences, Immunology, Oncology +17

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

François Ghiringhelli, Nicolas Larmonier, E. Schmitt et al. · European Journal of Immunology · 2004 · 868 citations

Life Sciences, Immunology, Oncology +17