Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

Xian Lin, Loukia Parisiadou, Xinglong Gu, +15

Neuron

Neurodegenerative DiseasesMolecular NeuroscienceNeurobiology Of DiseaseSynaptic SignalingExperimental Neuropathology +10

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

Mark A. Lovell, Chengsong Xie, William R. Markesbery

Neurobiology of Aging

Neurodegenerative DiseasesAlzheimer's DiseaseBiochemistryMedicineCell Death +10

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

Xinglong Gu, Cai-Xia Long, Lixin Sun, +3

Molecular Brain

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

Loukia Parisiadou, Chengsong Xie, Hyun Jin Cho, +8

Journal of Neuroscience

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein

Hyun Jin Cho, Guoxiang Liu, Seok Min Jin, +14

Human Molecular Genetics

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

Marcel P. van der Brug, Jeff Blackinton, Jayanth Chandran, +16

Proceedings of the National Academy of Sciences

MitophagyNeurodegenerative DiseasesDj-1 Supports InvolvementMitochondrial FunctionMedicine +12

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Nicolas Dzamko, Francisco Iñesta-Vaquera, Jiazhen Zhang, +10

PLoS ONE

Innate Immune SystemImmunologyImmune RegulationToll-like ReceptorImmunologic Mechanism +18

LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity

Loukia Parisiadou, Jia Yu, Carmelo Sgobio, +8

Nature Neuroscience

Signal TransductionMolecular PhysiologyMolecular NeuroscienceSignaling PathwayReceptor Tyrosine Kinase +11

Decreased thioredoxin and increased thioredoxin reductase levels in alzheimer’s disease brain

Mark A. Lovell, Chengsong Xie, S. Prasad Gabbita, +1

Free Radical Biology and Medicine

Neurodegenerative DiseasesAlzheimer's DiseaseMolecular NeuroscienceMedicineBrain Health +10

Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3

Mark A. Lovell, Shuling Xiong, Chengsong Xie, +2

Journal of Alzheimer s Disease

Hyperphosphorylated TauOxidative StressAlzheimer's DiseaseNeurofibrillary TanglesDegenerative Pathology +14