Erick A. Goldman

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor

Penglie Zhang, Wenrong Huang, Lingyan Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 105 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +10

Antimalarial Activities of Novel SyntheticCysteine ProteaseInhibitors

Belinda J. Lee, Ajay Singh, Peggy Chiang et al. · Antimicrobial Agents and Chemotherapy · 2003 · 77 citations · Full text

Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors:  P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties

J. Edward Semple, David Rowley, Terence K. Brunck et al. · Journal of Medicinal Chemistry · 1996 · 64 citations · Full text

P1-argininal Derivatives, Pharmaceutical Science, Thrombin Inhibitors +18

Inhibitory effect of carboxylic acid group on hERG binding

Bing‐Yan Zhu, Zhaozhong J. Jia, Penglie Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 51 citations · Full text

Biochemistry, G Protein-coupled Receptor, Receptor (Biochemistry) +2

Design and synthesis of a novel class of thrombin inhibitors incorporating heterocyclic dipeptide surrogates

Susan Y. Tamura, J. Edward Semple, John Reiner et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 32 citations

Combinatorial Chemistry, Medicinal Chemistry, Thrombin Inhibitors +10