Krishnamurthy Shyam

Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas

Philip G. Penketh, Krishnamurthy Shyam, Alan C. Sartorelli · Biochemical Pharmacology · 2000 · 82 citations

Dna Lesions, Medicine, Molecular Biology +6

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylamino)carbonylhydrazine (101M): a novel sulfonylhydrazine prodrug with broad-spectrum antineoplastic activity.

Rick A. Finch, Krishnamurthy Shyam, Philip G. Penketh et al. · PubMed · 2001 · 68 citations

Pharmaceutical Science, L1210 Leukemia, Chemoprevention Strategy +17

Generation of Oxygen Deficiency in Cell Culture Using a Two-Enzyme System to Evaluate Agents Targeting Hypoxic Tumor Cells

Raymond P. Baumann, Philip G. Penketh, Helen A. Seow et al. · Radiation Research · 2008 · 61 citations · Full text

Oxygen Deficiency, Cell Culture, Glioma +16

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: An anticancer agent targeting hypoxic cells

Helen A. Seow, Philip G. Penketh, Krishnamurthy Shyam et al. · Proceedings of the National Academy of Sciences · 2005 · 54 citations

Antitumor 2-(Aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines

Krishnamurthy Shyam, Philip G. Penketh, Regina Loomis et al. · Journal of Medicinal Chemistry · 1996 · 53 citations