¹³C Tracer Reveals Phenolic Acids Biosynthesis in Hairy Root Cultures of <i>Salvia miltiorrhiza</i>

Peng Di, Lei Zhang, Junfeng Chen, +5

ACS Chemical Biology

Secondary MetabolitePolyphenolicsPhenolic Acid BiosynthesisBiosynthesisMetabolic Engineering +15

Synthesis, Structure−Activity Relationship, and Biological Studies of Indolocarbazoles as Potent Cyclin D1-CDK4 Inhibitors

Guoxin Zhu, Scott E. Conner, Xun Zhou, +14

Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryHeterocyclicBiochemistryStructure−activity Relationship +12

Blockade of Autophagy Prevents the Progression of Hyperuricemic Nephropathy Through Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis

Yan Hu, Yingfeng Shi, Hui Chen, +6

Frontiers in Immunology

Dynamic metabolic and transcriptomic profiling of methyl jasmonate‐treated hairy roots reveals synthetic characters and regulators of lignan biosynthesis in <i>Isatis indigotica</i> Fort

Lei Zhang, Junfeng Chen, Xun Zhou, +7

Plant Biotechnology Journal

Transcriptomic ProfilingGeneticsPlant MetabolomicsBiosynthesisMetabolic Engineering +15

Biosynthesis of the active compounds of Isatis indigotica based on transcriptome sequencing and metabolites profiling

Junfeng Chen, Xin Dong, Qing Li, +6

BMC Genomics

Autologous blood transfusion augments impaired wound healing in diabetic mice by enhancing lncRNA H19 expression via the HIF-1α signaling pathway

Jian‐Rong Guo, Lei Yin, Yongquan Chen, +6

Cell Communication and Signaling

Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury

Jianrong Guo, Huan Wang, Jin Xiao-ju, +3

Oncotarget

Overexpression of allene oxide cyclase promoted tanshinone/phenolic acid production in Salvia miltiorrhiza

Xiao-Ce Gu, Junfeng Chen, Ying Xiao, +5

Plant Cell Reports

BiosynthesisBioorganic ChemistryTanshinone/phenolic Acid ProductionBiochemistryEngineering +7

Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles

Thomas A. Engler, Kelly Furness, Sushant Malhotra, +24

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePharmacological AgentPharmacologyPharmaceutical Chemistry +1

Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells

Guangzhi Li, Yongting Qin, Shuang-li Qin, +3

Life Sciences

InflammationInflammatory ResponsesFibrosisMolecular PhysiologyMedicine +9