Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Jeffrey A. Bluestone, Jane H. Buckner, Mark Fitch, +15

Science Translational Medicine

Translational MedicineDiabetes ManagementAutoimmune DiseaseT-regulatory CellDiabetes +11

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

Alana G. Lerner, John-Paul Upton, Paurush Praveen, +14

Cell Metabolism

InflammationIrremediable Er StressSignal TransductionThioredoxin-interacting ProteinSignaling Pathway +9

Landscape of stimulation-responsive chromatin across diverse human immune cells

Diego Calderon, Michelle Nguyen, Anja Mezger, +17

Nature Genetics

ChromatinChromatin RemodelingImmunologyStimulation-responsive ChromatinCellular Immune Response +3

CRISPR activation and interference screens decode stimulation responses in primary human T cells

Ralf Schmidt, Zachary Steinhart, Madeline Layeghi, +6

Science

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismGenome-wide Crispr Activation +22

Obesity alters pathology and treatment response in inflammatory disease

Sagar P. Bapat, Caroline Whitty, Cody T. Mowery, +40

Nature

ObesityMetabolic SyndromeInflammationChronic Inflammatory DiseasesAnti-inflammatory +5

The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes

Shen Dong, Kamir J. Hiam-Galvez, Cody T. Mowery, +17

JCI Insight

Type 1Cell TherapyDiabetes ManagementAutoimmune DiseaseTreg Populations +13

The SIRPα–CD47 immune checkpoint in NK cells

T. Deuse, Xiaomeng Hu, Sean Agbor-Enoh, +9

The Journal of Experimental Medicine

Attenuation of Donor-Reactive T Cells Allows Effective Control of Allograft Rejection Using Regulatory T Cell Therapy

Kyoungtae Lee, Vinh Nguyen, K.-M. Lee, +2

American Journal of Transplantation

Cell TherapyT-regulatory CellImmunologyImmune RegulationTreg Therapy +19

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity

Kathrin Schumann, Siddharth S. Raju, Michael Lauber, +18

Nature Immunology

Off-target EffectFunctional GenomicsEngineeringGene NetworksGenetics +10

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Yannick D. Müller, Leonardo M. R. Ferreira, Émilie Ronin, +13

Frontiers in Immunology