Alexander D. James

Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism

Ulrike Glaenzel, Yi Jin, Robert Nufer et al. · Drug Metabolism and Disposition · 2018 · 55 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +14

Absorption, distribution, metabolism, and excretion of [14C]BYL719 (alpelisib) in healthy male volunteers

Alexander D. James, Lars Blumenstein, Ulrike Glaenzel et al. · Cancer Chemotherapy and Pharmacology · 2015 · 42 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +6

Ultra‐performance liquid chromatography coupled to linear ion trap mass spectrometry for the identification of drug metabolites in biological samples

Gordon J. Dear, Alexander D. James, Sunil Sarda · Rapid Communications in Mass Spectrometry · 2006 · 31 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +17

An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data

Alexander D. James, Hilmar Schiller, Cyrille Marvalin et al. · Pharmacology Research & Perspectives · 2020 · 31 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Comparison of 19F NMR and 14C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans

Alexander D. James, Cyrille Marvalin, Alexandre Luneau et al. · Drug Metabolism and Disposition · 2017 · 30 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17