Roger D. Klein

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Caitlin N. Spaulding, Roger D. Klein, Ségolène Ruer et al. · Nature · 2017 · 306 citations

Urology, Medicine, Gastroenterology +9

Antivirulence <i>C</i>-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

Laurel Mydock‐McGrane, Zachary Cusumano, Zhenfu Han et al. · Journal of Medicinal Chemistry · 2016 · 118 citations · Full text

Glycobiology, Antimicrobial Chemotherapy, Drug Resistance +20

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

Cassie M. Jarvis, Zhenfu Han, Vasilios Kalas et al. · ChemMedChem · 2016 · 68 citations · Full text

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation

Roger D. Klein, Qin Shu, Zachary Cusumano et al. · mBio · 2018 · 44 citations · Full text

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic <i>E. coli</i> (UPEC): Optimization through Iterative Rational Drug Design

Amarendar Reddy Maddirala, Roger D. Klein, Jerome S. Pinkner et al. · Journal of Medicinal Chemistry · 2018 · 27 citations · Full text