Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis

Hao Gu, Chiqi Chen, Xiaoxin Hao, +22

Journal of Clinical Investigation

Protein SecretionProtein Vps33bExtracellular MicrovesiclesExosomal AutocrineMyeloid Neoplasia +16

Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats

Jiangbo Wan, Liulu Xia, Wenjia Liang, +2

Journal of Diabetes Research

Tissue EngineeringCell TherapyEngineeringAdult Stem CellBiomedical Engineering +15

Enhancement of Anti-Leukemia Immunity by Leukemia–Derived Exosomes Via Downregulation of TGF-β1 Expression

Fang Huang, Jiangbo Wan, Weiwei Hu, +1

Cellular Physiology and Biochemistry

Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models

Xiaoxiao He, Jiangbo Wan, Xiaona Yang, +14

Journal of Clinical Investigation

TGF-β1-silenced leukemia cell-derived exosomes target dendritic cells to induce potent anti-leukemic immunity in a mouse model

Fang Huang, Jiangbo Wan, Siguo Hao, +3

Cancer Immunology Immunotherapy

Cancer ImmunosurveillanceAdaptive Immune SystemImmune RegulationTumor ImmunityImmunology +8

Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors

Fatma Babikr, Jiangbo Wan, Aizhang Xu, +9

Cellular and Molecular Immunology

Tumor ImmunologyCancer ImmunosurveillancePd-1 BlockadeImmunologyImmunoediting +8

MCL-1 or BCL-xL-dependent resistance to the BCL-2 antagonist (ABT-199) can be overcome by specific inhibitor as single agents and in combination with ABT-199 in acute myeloid leukemia cells

Qing Wang, Jiangbo Wan, Wenhao Zhang, +1

Leukemia & lymphoma/Leukemia and lymphoma

Enhanced immunogenicity of leukemia-derived exosomes via transfection with lentiviral vectors encoding costimulatory molecules

Weiwei Hu, Fang Huang, Liuxin Ning, +3

Cellular Oncology

CD274 promotes cell cycle entry of leukemia-initiating cells through JNK/Cyclin D2 signaling

Xia Fang, Chiqi Chen, Fangzhen Xia, +12

Journal of Hematology & Oncology

Construction of lncRNA-related ceRNA regulatory network in diabetic subdermal endothelial cells

Jiangbo Wan

Bioengineered

BioinformaticsFunctional GenomicsMultiple LncrnasMicrovascular DysfunctionDiabetes +13