Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma

Genze Shao, Rouli Zhou, Qingyun Zhang, +5

Oncogene

HepatologyNovel GeneLiver PhysiologyPathologyCancer Genomics +9

Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit

Jie Wang, Keke Fei, Jing Hua, +11

mAbs

ImmunologyImmunoeditingPathologyPharmacotherapyImmunotherapy +22

Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity

Yan Wang, Haiqing Ni, Shuaixiang Zhou, +15

Cancer Immunology Immunotherapy

Cancer ImmunosurveillanceMedicineImmunologyTumor ImmunityLimited Toxicity +8

PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunity

Haiping Jiang, Haiqing Ni, Pan Zhang, +12

OncoImmunology

Combined Genetic Assessment of Transforming Growth Factor-β Signaling Pathway Variants May Predict Breast Cancer Risk

Virginia Kaklamani, Lisa Baddi, Junjian Liu, +14

Cancer Research

Targeting C3b/C4b and VEGF with a bispecific fusion protein optimized for neovascular age-related macular degeneration therapy

Shiqi Yang, Tong Li, Huixun Jia, +19

Science Translational Medicine

Ocular DiseaseImmunologyCell DeathRetinal TherapiesImmunotherapy +17

Preclinical characterization of Sintilimab, a fully human anti-PD-1 therapeutic monoclonal antibody for cancer

Shuang Zhang, Min Zhang, Weiwei Wu, +9

Antibody Therapeutics

Development and characterization of a novel anti-OX40 antibody for potent immune activation

Zhihui Kuang, Jing Hua, Zhihai Wu, +14

Cancer Immunology Immunotherapy

Autoimmune DiseaseAllergyPotent Immune ActivationImmunologyAntibody Screening +8

Combined strategies for effective cancer immunotherapy with a novel anti-CD47 monoclonal antibody

Haiqing Ni, Lei Cao, Zhihai Wu, +18

Cancer Immunology Immunotherapy

Tumor ImmunologyCancer ImmunosurveillanceMedicineImmunologyTherapeutic Vaccine +9

A new hybrid algorithm for three-stage gene selection based on whale optimization

Junjian Liu, Chiwen Qu, Lupeng Zhang, +5

Scientific Reports