Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,

Dongwen Lv, Pratik Pal, Xingui Liu, +21

Nature Communications

CovalentDock: Automated covalent docking with parameterized covalent linkage energy estimation and molecular geometry constraints

Xuchang Ouyang, Shuo Zhou, Chinh Tran-To Su, +3

Journal of Computational Chemistry

Piperlongumine conjugates induce targeted protein degradation

Jing Pei, Yufeng Xiao, Xingui Liu, +14

Cell chemical biology

Drug TargetBiochemistryNatural SciencesBioconjugationChemical Biology +1

Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR41 and GPR43

Zifan Wang, Cai Wang, Boyu Yuan, +10

Microbiome

Adhesion and activation of platelets from subjects with coronary artery disease and apparently healthy individuals on biomaterials

S. Braune, Michael Groß, Michael Walter, +6

Journal of Biomedical Materials Research Part B Applied Biomaterials

Healthy IndividualsEngineeringHealthy SubjectsBiomedical EngineeringCoronary Artery Disease +16

Structural insights into BCDX2 complex function in homologous recombination

Yashpal Rawal, Lijia Jia, Aviv Meir, +16

Nature

Bcdx2 Complex FunctionChromosomal RearrangementRecombination DynamicMolecular Biology

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

Kai Ding, Ziyuan Zhou, Shurong Hou, +7

Scientific Reports

Product analysis and mechanism of toluene degradation by low temperature plasma with single dielectric barrier discharge

Fenglei Han, Mengyu Li, Zhong Huangrong, +5

Journal of Saudi Chemical Society

Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water

Yan Xu, Shuo Zhou, Yuanqiang Wang, +3

Tetrahedron

Tandem SynthesisChemical EngineeringEngineeringOrganic ChemistryChemistry +2

CovalentDock Cloud: a web server for automated covalent docking

Xuchang Ouyang, Shuo Zhou, Zemei Ge, +2

Nucleic Acids Research

Cluster ComputingChemistryMolecular GraphicMolecular RecognitionComputational Biochemistry +15