Jan Grünewald

Synthesis and Derivatization of Daptomycin:  A Chemoenzymatic Route to Acidic Lipopeptide Antibiotics

Jan Grünewald, Stephan A. Sieber, Christoph Mahlert et al. · Journal of the American Chemical Society · 2004 · 129 citations

Bioorganic Chemistry, Engineering, Acidic Lipopeptide Antibiotics +17

Peptide Macrocyclization:  The Reductase of the Nostocyclopeptide Synthetase Triggers the Self-Assembly of a Macrocyclic Imine

Florian Kopp, Christoph Mahlert, Jan Grünewald et al. · Journal of the American Chemical Society · 2006 · 74 citations

Engineering, Peptide Engineering, Peptide Cyclization +16

Loss of CD4 T-cell–dependent tolerance to proteins with modified amino acids

Varun Gauba, Jan Grünewald, Vanessa Gorney et al. · Proceedings of the National Academy of Sciences · 2011 · 62 citations

Chemoenzymatic Design of Acidic Lipopeptide Hybrids:  New Insights into the Structure−Activity Relationship of Daptomycin and A54145

Florian Kopp, Jan Grünewald, Christoph Mahlert et al. · Biochemistry · 2006 · 59 citations

Chemo- and Regioselective Peptide Cyclization Triggered by the N-Terminal Fatty Acid Chain Length:  The Recombinant Cyclase of the Calcium-Dependent Antibiotic from <i>Streptomyces coelicolor</i>

Jan Grünewald, Stephan A. Sieber, Mohamed A. Marahiel · Biochemistry · 2004 · 54 citations