In this study, 12 pairs of tautomeric flavonol derivatives containing quinoxaline were synthesized. The results of antifungal activity showed that in the enol-keto tautomerism, the target compounds containing keto (Y_B series) had better inhibitory activity against Sclerotinia sclerotiorum (S.s.) than compounds containing enol (Y_A series). Y_B9 showed the strongest antifungal activity against S.s., and the median effective concentration (EC₅₀) value was 1.0 μg/mL, which was better than azoxystrobin (Az, 35.3 μg/mL). In vivo fungal inhibition experiments showed that the protective activity of Y_B9 against rape leaves was 83.4% at 200 μg/mL, which was superior to that of Az (70.2%). The activity of succinate dehydrogenase and molecular docking results showed that Y_B9 had a stronger antifungal effect than Y_A9. The results of oxalic acid content determination showed that Y_B9 could reduce the pathogenic ability of S.s. Then, the inhibitory effect of Y_B9 against S.s. was further verified by scanning electron microscopy, fluorescence microscopy, cell membrane permeability, cell content leakage, and malondialdehyde content.

#	Concept	H-Index	Publications	Citations
1	Medicine	1	1	25
2	Natural Sciences	1	1	25
3	Microbiology	1	1	25
4	Pharmacology	1	1	25
5	Bioorganic Chemistry	1	1	25

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