Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Paul A. Northcott, David Shih, John Peacock, +131

Nature

GeneticsGenomicsCancer BiologyTumor BiologyNeuro-oncology +21

Divergent clonal selection dominates medulloblastoma at recurrence

A. Sorana Morrissy, Livia Garzia, David Shih, +134

Nature

Neuro-oncologySomatic VariantTumor HeterogeneityMedicineGenetics +3

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

Robert J. Vanner, Marc Remke, Marco Gallo, +25

Cancer Cell

BiologyCell LineageDevelopmental BiologyCell DivisionMorphogenesis +2

Spatial heterogeneity in medulloblastoma

A. Sorana Morrissy, Florence M.G. Cavalli, Marc Remke, +76

Nature Genetics

BiologyNeuro-oncologyProtistSpatial HeterogeneityHistopathology +2

The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Anita Villani, Scott Davidson, Nisha Kanwar, +48

Nature Cancer

EngineeringSickkids Cancer SequencingPathologyIntegrative GenomicsTumor Heterogeneity +14

How the Mountain Pine Beetle (Dendroctonus ponderosae) Breached the Canadian Rocky Mountains

Jasmine K. Janes, Yisu Li, Christopher I. Keeling, +8

Molecular Biology and Evolution

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

Sekyung Oh, Ryan A. Flynn, Stephen N. Floor, +25

Oncotarget

JAGuaR: Junction Alignments to Genome for RNA-Seq Reads

Yaron S.N. Butterfield, Maayan Kreitzman, Nina Thiessen, +6

PLoS ONE

Long-read SequencingMultiple ExonsTranscriptome AlignmentsFunctional GenomicsJunction Alignments +13

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation

Katherine Tech, Andrey P. Tikunov, Hamza Farooq, +15

Cancer Research

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma

Daniel Merk, Jasmin Ohli, Natalie D. Merk, +34

Developmental Cell

Rubinstein-taybi SyndromeMendelian DisorderGenetic DisorderCrebbp Mutations GovernGenetics +5