Near-infrared spectroscopy (NIRS) measurement of postocclusive reactive hyperaemia (PORH) tissue oxygen saturation reperfusion rate [STO₂ upslope (as a percentage per minute)] has recently been correlated with the percentage of flow-mediated dilatation (%FMD). Cardiovascular disease is associated with impairments in %FMD. Reduced insulin sensitivity may negatively affect the vascular system for many years before prediabetes/type 2 diabetes states. The aim of this study was to determine whether static and dynamic STO₂ parameters during PORH are correlated with reduced insulin sensitivity in young, normoglycaemic subjects. Glucose and insulin were measured during an oral glucose tolerance test in 18- to 26-year-old, healthy subjects (11 men and 11 women), and STO₂ was measured during PORH of antebrachial muscle. Hepatic (ISI_HOMA ) and whole-body (ISI_COMP ) insulin sensitivities were calculated. The STO₂ upslope was negatively correlated with minimal STO₂ (r = -0.5, P = 0.01). The change of STO₂ from minimum to baseline (ΔSTO₂ ) was significantly negatively correlated with fasting insulin (r = -0.5, P = 0.01) and a positively correlated with ISI_HOMA (r = 0.65, P = 0.001). The minimum STO₂ was significantly negatively correlated with ISI_HOMA , and STO₂ upslope was significantly positively correlated with ISI_HOMA (r = 0.44, P = 0.02). The minimum STO₂ (a measure of O₂ extraction while the cuff was inflated), ΔSTO₂ (a measure of the amount of reperfusion) and STO₂ upslope (a measure of responsiveness of the microcirculation to ischaemia) were all positively correlated with ISI_HOMA , one of the longest-used measures of insulin sensitivity. The NIRS-derived STO₂ might be a useful tool for assessing how levels of reduced insulin sensitivity in young, normoglycaemic adults affect the microvasculature.

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