Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription

Wenzhuo Zhuang, Xueping Ge, Sijun Yang, +7

Stem Cells

Bone Marrow MscsSclerostinOsteoporosisRegenerative MedicineTranscriptional Regulation +14

Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

Pi‐Xiao Wang, Xiao‐Jing Zhang, Pengcheng Luo, +8

Nature Communications

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

Heshan Peiris, Michael D. Duffield, João Fadista, +29

PLoS Genetics

Metabolic DisorderMitochondrial DysfunctionGeneticsMolecular GeneticsInsulin Signaling +17

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

Sijun Yang, Chunxiang Xia, Shali Li, +3

Redox Biology

Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line

Shali Li, Leilei Du, Lu Zhang, +8

Journal of Biological Chemistry

MitophagyImmunologyImmune RegulationCell DeathCell Death Mechanisms +20

Celastrol prevents cadmium‐induced neuronal cell death by blocking reactive oxygen species‐mediated mammalian target of rapamycin pathway

Ruijie Zhang, Nana Zhang, Hai Zhang, +9

British Journal of Pharmacology

Inhibition of Miro1 disturbs mitophagy and pancreatic β-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes

Lingling Chen, Chunyan Liu, Jianfeng Gao, +9

Oncotarget

Combination therapy of gefitinib and miR-30a-5p may overcome acquired drug resistance through regulating the PI3K/AKT pathway in non-small cell lung cancer

Fengfeng Wang, Fei Meng, Sze Chuen Cesar Wong, +3

Therapeutic Advances in Respiratory Disease

Hepatic Oncostatin M Receptor β Regulates Obesity-Induced Steatosis and Insulin Resistance

Pengcheng Luo, Pi‐Xiao Wang, Zuo-Zhi Li, +8

American Journal Of Pathology

ObesityInflammationMetabolic SyndromeInsulin ResistanceHepatology +13

Miro1-mediated mitochondrial dysfunction under high nutrient stress is linked to NOD-like receptor 3 (NLRP3)-dependent inflammatory responses in rat pancreatic beta cells

Jianfeng Gao, Ming Sang, Xiaoyu Zhang, +5

Free Radical Biology and Medicine

InflammationInflammatory ResponsesMitophagyHigh Nutrient StressMolecular Physiology +13