Hong Fu

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

Robert McDaniel, Arinthip Thamchaipenet, Claes Gustafsson et al. · Proceedings of the National Academy of Sciences · 1999 · 461 citations

Engineering, Biological Engineering, Biotechnology +17

Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase

Hong Fu, Susanne Ebert‐Khosla, David A. Hopwood et al. · Journal of the American Chemical Society · 1994 · 113 citations

Engineering, Biotechnology, Chemistry +14

Dissecting the Role of Acyltransferase Domains of Modular Polyketide Synthases in the Choice and Stereochemical Fate of Extender Units

Janice Lau, Hong Fu, David E. Cane et al. · Biochemistry · 1999 · 88 citations

Pharmacy, Biochemistry, Molecular Biology +15

Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor

Hong Fu, David A. Hopwood, Chaitan Khosla · Chemistry & Biology · 1994 · 81 citations

Engineering, Biological Engineering, Biotechnology +12

Alcohol Stereochemistry in Polyketide Backbones Is Controlled by the β-Ketoreductase Domains of Modular Polyketide Synthases

Camilla M. Kao, Michael J. McPherson, Robert McDaniel et al. · Journal of the American Chemical Society · 1998 · 79 citations

Pharmacy, Biochemistry, Biocatalysis +11